Reportedly, researchers have used a cryo-electron microscopy to obtain the structure of a proportion of the telomerase enzyme, opening the possibility of either inhibiting it on to stop cancer or activating it to prevent ageing. There is, of course, a lot more work than this that needs to be done before it becomes viable in the mean time, maybe we can self-repair our organs as needed.
Organisms regulate their telomere maintenance in this way because they are walking a biological tightrope. On the one hand, they need to replace the cells they lose in the course of their ordinary daily lives by cell division.
However, any cell with an unlimited capacity to divide is the seed of a tumour. And it turns out that the majority of human cancers have active telomerase and shorter telomeres than the cells surrounding them.
This indicates that the cell from which they came divided as normal but then picked up a mutation which turned TERT back on. Cancer and ageing are flip sides of the same coin and telomerase, by and large, is doing the flipping.
|Enough is Enough: Nuke the Oil Spill|
|The "Post-Antibiotic Era" Has Begun|
|"Imagine if you cut a person in half at the waist, the bottom half would grow a new head and the top half would grow new legs."|
|Bioengineering the End of Ageing|
|Living in a Community You Can Never Leave|
|“The direction of the cost of storage is less clear and depends on metals prices.”|
|“The era of climate wars has begun.”|
|Facebook, Twitter Users Could Face Insurance Hikes|
|"Waymo is reportedly planning to take the next step towards offering a commercial driverless car service in early December."|
|The (Very Scary) People of Public Transit|
|How to Avoid Jury Duty|
|Naked Preacher Lady [NSFW]|
|Boardwalk Empire: Time Lapse Video|
|Fake Name Generator|
|Pat the Zombie: A Cruel Adult Spoof of 'Pat the Bunny'|
|“Bias, error, and misuse of Artificial Intelligence technologies.”|
|“We need to make algorithms transparent, regulated, and forgiving of the flawed creatures that converse with them.”|