The Blind Film Critic, who is indeed blind and reviews movies, shows you how he uses his iPhone to take pictures with Instagram. It's actually quite impressive how well developed the iPhone is to provide enough feedback to a user to determine what they're touching.
Tommy Edison, who has been blind since birth, demonstrates how to use Instagram on the iPhone 4S. He uses the Accessibility setting on the phone which allows him to navigate the touch-screen and some applications.
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