"The unique DNA fingerprint of fusion genes could be their own undoing."

Using CRISPR-Cas9 to target cancer

#Health

Wed, May 3rd, 2017 11:00 by capnasty NEWS

According to New Atlas, researchers from the University of Pittsburgh have used CRISPR-Cas9, the genome editing system, to target a cancer's "command centre," effectively reducing a tumor by 30% and preventing further growth. It works by delivering new DNA targeting those command genes via a virus and replacing them with a cancer-killing ones.

In the University of Pittsburgh study, the team transplanted human prostate and liver cancer cells into mice, then treated one group with the CRISPR tool that targets those fusion genes. As a result, the tumors shrunk by up to 30 percent, didn't spread through the body, and the animals all survived to the end of the eight-week test. Meanwhile, in a control group that received the same treatment targeting fusion genes that weren't present in their bodies, the tumors grew almost 40 times larger and in most cases, spread to other parts of the body. None of the control group survived to the end of the test period.

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