"Prevention of aging is an instinctive desire of humans."

Lost functions in aging cells restored with protein inhibitor

#Health

Thu, Apr 6th, 2017 11:00 by capnasty NEWS

Aging is caused by the degradation of lysosomes, intracellular organelles that act as the disposal system of the cell. As the lysomes cease to function, cellular senescence occurs, causing cells to fail to divide and eventually die. Reportedly, researchers have discovered that using KU-60019, an ATM protein inhibitor, "restores the functions of aging cells through activation of lysosomal functions and induction of cell proliferation."

The research confirmed that as cell aging progresses, the vacuolar ATPase (v-ATPase) protein involved in the lysosomal activity regulation is phosphorylated by the ATM protein, and the binding force between the units constituting the v-ATPase is weakened, so consequently the function of lysosomes deteriorates. In addition, the team has proven that the reversible recovery of aging is possible. They experimentally demonstrated that the regulation of ATM protein activation by KU-60019 substances induces the reduction of phosphorylation of v-ATPase, thereby inducing recovery of mitochondrial function and functional recovery of the lysosome and autophagy system as well as promoting wound healing in aging animal models.

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