Working with the speculation that "the blood of young people contains substances that might rejuvenate older adults," two teams of scientists discovered that the blood of young mice "reverses aging in old mice"
[In the 1950s,] Dr. McCay and his colleagues performed necropsies and found that the cartilage of the old rats looked more youthful than it would have otherwise. But the scientists could not say how the transformations happened. There was not enough known at the time about how the body rejuvenates itself.
It later became clear that stem cells are essential for keeping tissues vital. When tissues are damaged, stem cells move in and produce new cells to replace the dying ones. As people get older, their stem cells gradually falter.
In the early 2000s, scientists realized that stem cells were not dying off in aging tissues.
There were plenty of stem cells there, recalled Thomas A. Rando, a professor of neurology at Stanford University School of Medicine. They just dont get the right signals.
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